In the successful series of Semantic Grid and e-Science events we intend to bring together researchers and practitioners around the world from the quickly developing research areas of the Semantic Web, Grid and e-Science. As semantic technologies are being widely accepted in various e-science areas such as life science or bioinformatics, it is necessary and urgent to offer semantically enriched methods, tools, middleware to facilitate semantic modeling, system building, searching, and data analyzing in e-science applications. Former Semantic Grid research aimed at the Grid level, in which often the basic premises of the science-like environment are forgotten or disregarded. Thus the main goal of this workshop is to lay the foundations for e-Science within the Semantic Web scenario.

The aim of this workshop is to ground Semantic e-Science firmly on the needs of the Semantic Web and general science research community. We want to encourage and stimulate discussion about the current state of the art in Semantic e-Science and its future direction. Currently, ontologies and the Semantic Web attract researchers from all around the world and from various disciplines. There have been many approaches of using ontologies in the e-Science domain, which has been introduced in several past Semantic Grid and e-Science events. However, the role of ontology in the Semantic e-Science research has still not been unambiguously formalized. On the other hand, ontology-based tools for various e-Science branches have been widely developed and already attracted the attention from traditional science research community and provided real cases and experience for applying Semantic Web technologies. We regard it as necessity to set a research agenda at this point in time, in order to steer the development and the research efforts in the most rewarding direction towards our common goal of realizing the Semantic e-Science. Otherwise we fear that effort, motivation and funding may be invested less effectively, slowing the realization and adaptation of the Semantic Web technology in the e-Science research. Furthermore, there is also a great opportunity for the building the collaboration between the EU and non-EU universities, especially Asian universities, which locate at the one of the most active economical areas around the world. The holding of this workshop would help to build closer connection between researchers from both sides, and consolidate the collaborations.

Main topics of interest include but are not limited to:
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Semantic e-Science Foundations:
* Semantic Infrastructure and Architecture for e-Science
* Semantic Web and Grid middleware
* Service Oriented Architecture for Semantic Grid
* Scalability and flexibility of e-Science infrastructure
* Semantic Data Integration for e-Science
* Semantic Web services for e-Science
* Ontology Engineering for e-Science
* Web Trust for e-Science
* Knowledge Management for e-Science
* Complex e-Science Process Management
* Complex Semantic Network

Semantic Web Applications and Ontologies for:
* System Biology, Bio&Medical Informatics
* Complex Biological Network Modeling.
* Geography, Environment and Climate
* Chemistry, Physics and Mechanics
* Web Service applications
* P2P applications
* Digital Libraries and Scientific Publication
* Ubiquitous and Mobile Semantic Web applications
* Information Retrieval and Machine Learning
* HCI issues and Usability
* Case study and user issues

Submission and Proceedings
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Interested authors should submit an electronic PDF and source version of their papers to *Yimin Wang* prior to the paper submission deadline. The first page of submitted papers should include: title, author names, affiliations, postal addresses, electronic mail addresses, telephone and fax numbers for all authors, and a brief abstract. All correspondence will be sent to the author mentioned as contact person in the electronic title page (by default, the first author). Regualr submissions should not exceed 10 pages and should be formatted according to the guidelines of the Springer Lecture Notes. Posters and demos should be submitted up to 4 pages LNCS format.

The workshop proceedings will be published in electronic version online. Extended version of selected papers will be published as a supplement issue of *BMC Bioinformatics* journal (confirmed) and *CAI* (confirmed), depending on the different aspects of proceedings. The workshop proceedings have good chance to be selected to these two journal special issues.

BMC Bioinformatics is a respectable, SCI indexed journal with a focus on bio/medical informatics, with impactor 5.2. CAI is an active journal which is also SCI-indexed.

Important Dates
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Full Paper Submission Deadline: July 15th, 2006
Notification of acceptance: July 30th, 2006
Camera ready deadline: August 10th, 2006
Workshop date: September 3th or 4th, 2006 (to be settled)

Organization Committee
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Yimin Wang (co-chair)
Institute AIFB, University of Karlsruhe, Gemany
ywa@aifb.uni-karlsruhe.de

Huajun Chen (co-chair)
CCNT, Zhejiang University, China
huajunsir@zju.edu.cn

Peter Haase
Institute AIFB, University of Karlsruhe, Germany
pha@aifb.uni-karlsruhe.de

Zhaohui Wu
CCNT, Zhejiang University, China
wzh@cs.zju.edu.cn

Rudi Studer
Institute AIFB, University of Karlsruhe, Germany
studer@aifb.uni-karlsruhe.de

Program Committee
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Nigel Shadbolt, University of Southampton, UK
Nong Xiao, National Defense University, China
York Sure, University of Karlsruhe, Germany
Jeff Pan, University of Aberdeen, UK
Minglu Li, Shanghai Jiaotong University, China
Rudi Studer, University of Karlsruhe, Germany
Keqing He, Wuhan University, China
Christopher Baker, Concordia University, Canada
Yanbo Han, China Academy of Science, China
Heiner Stuckenschmidt, University of Mannheim, Germany
BingLi, Wuhan University, China
Kei Cheung, Yale University, USA
William Cheng, Hong Kong Baptist University, China
Takahira Yamaguchi, Keio University, Japan
Robert Stevens, University of Manchester, UK
Jacek Kitowski, AGH University of Science and Technology, Poland
Hai Wang, University of Machester, UK